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Diagnostic test accuracy reviews 4: Introduction to meta-analysis.

Topic category Diagnostic test accuracy review methods
Date and Location
Thursday 20 October 2011 - 14:00 - 15:30
Methods Group
Methods Group: 
Screening and Diagnostic Tests Methods Group
Contact person
Contact person: 
Jon Deeks (Contact this person)
First nameLast nameAffiliation and Country
First name: 
Last name: 
Affiliation and Country: 
DTA Working Group, UK
First name: 
Last name: 
Affiliation and Country: 
DTA Working Group, UK
Target audience
Target audience: 
Review authors undertaking DTA reviews
Is your workshop restricted to a specific audience or open to all Colloquium participants?: 
Level of knowledge required: 
Type of workshop
Type of workshop: 
Abstract text
The Cochrane Diagnostic Reviews Methodology Working Group has developed a series of workshops addressing guidelines as formulated in the Handbook for Diagnostic Test Accuracy reviews. This workshop is designed to introduce the principles of meta-analysis of diagnostic test accuracy studies.

We will present a framework for meta-analysis of diagnostic accuracy studies as is implemented within the Cochrane Diagnostic test accuracy reviews. We will start with an overview of the various statistics to express the diagnostic performance of an index test, such as sensitivity, specificity, likelihood ratios and diagnostic odds ratios. Then methods for graphically summarising results from original studies will be presented: forest plots of sensitivity and specificity, and the ROC plot for presenting paired sensitivity-specificity results. Basic methods for estimating a summary ROC-curve will be presented as they are implemented in RevMan 5, and the rationale for using these methods explained. The workshop will conclude with an overview of possible sources of heterogeneity and methods for assessing heterogeneity.