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A measurement tool to assess the methodological quality of systematic reviews of non-randomized studies (AMSTAR NRS)

Topic category Investigating bias
Date and Location
Fecha: 
Sábado 22 Octubre 2011 - 14:00 - 15:30
Location: 
Methods Group
Methods Group: 
Non-Randomised Studies Methods Group
Contact person
Contact person: 
Beverley Shea (Contact this person)
Facilitators
NombreApellidoAffiliation and Country
Nombre: 
Beverley
Apellido: 
Shea
Affiliation and Country: 
CIET, Canada
Nombre: 
George
Apellido: 
Wells
Affiliation and Country: 
University of Ottawa, Canada
Other contributors
NombreApellidoAffiliation and Country
Nombre: 
David
Apellido: 
Moher
Affiliation and Country: 
University of Ottawa, Canada
Nombre: 
Barney
Apellido: 
Reeves
Affiliation and Country: 
Non-Randomised Studies Methods Group
Nombre: 
David
Apellido: 
Henry
Affiliation and Country: 
ICES, Canada
Nombre: 
Peter
Apellido: 
Tugwell
Affiliation and Country: 
University of Ottawa
Nombre: 
Neil
Apellido: 
Andersson
Affiliation and Country: 
CIET, Canada
Target audience
Target audience: 
Reviewers
Is your workshop restricted to a specific audience or open to all Colloquium participants?: 
Open
Level of knowledge required: 
Any
Type of workshop
Type of workshop: 
Training
Abstract text
Abstract: 
Since we introduced it in 2007 AMSTAR, which was developed and validated against RCTs, has become widely used for assessing the quality of systematic reviews (SRs). However, over half of published SRs now include non-randomized studies (NRS). Many of these reviews of disease associations and treatment effects cover topics that are of considerable significance to clinicians and policy makers. NRS are prone to a range of biases, and poor quality SRs that include these designs can be misleading. It is important to develop an instrument that enables users of such reviews to make a rapid and accurate appraisal of their quality. We intend to develop and validate a new instrument, AMSTAR NRS, which will be better suited to this purpose.
The workshop will include a discussion of the methodological challenges in the evaluation of SRs of NRS. We will present participants with SRs that include NRS and provide them with an opportunity to use AMSTAR to perform an assessment of their quality. Small group discussions will also allow us to gain knowledge about the experiences of using AMSTAR to assess the quality of reviews that include NRS and to get suggestions for developing an instrument for assessing SRs of NRS.