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Classifying non-randomised studies (NRS) and the assessing the risk of bias for a systematic review

Topic category Investigating bias
Date and Location
Date: 
Friday 21 October 2011 - 16:00 - 17:30
Location: 
Methods Group
Methods Group: 
Non-Randomised Studies Methods Group
Contact person
Contact person: 
Barnaby Reeves (Contact this person)
Facilitators
First nameLast nameAffiliation and Country
First name: 
Barnaby
Last name: 
Reeves
Affiliation and Country: 
Non-Randomized Studies Methods Group
Other contributors
First nameLast nameAffiliation and Country
First name: 
Bev
Last name: 
Shea
Affiliation and Country: 
University of Ottawa
First name: 
George
Last name: 
Wells
Affiliation and Country: 
University of Ottawa
Target audience
Target audience: 
Reviewers and editors considering whether or not to include non-randomised studies (NRS) in Cochrane systematic reviews
Is your workshop restricted to a specific audience or open to all Colloquium participants?: 
Open
Level of knowledge required: 
Intermediate
Type of workshop
Type of workshop: 
Training
Abstract text
Abstract: 
Objectives:
The workshop aims to improve awareness of the key issues when including NRS in systematic reviews of effectiveness.
Description:
This workshop is aimed at review authors and editors who are considering whether or not to include non-randomised studies (NRS) in review to estimate the benefits of an intervention. This situation may arise when there are no RCTs, only poor RCTs or very few small RCTs, but where the question addressed by the review is a priority. Evaluations of public health, practitioner-dependent or device-based interventions may have these limitations. Participants will mainly work in small groups to apply tools developed by the NRSMG to a single NRS. First, participants will classify the NRS with respect to study features (likely to be relevant to setting review eligibility criteria) which the NRSMG recommends extracting from primary studies. Second, participants will assess the risk of bias in the NRS using an extended risk-of-bias tool. The implications of varying amounts and quality of information from primary NRS for systematic reviews of NRS will be discussed. Varying amounts and quality of information is also the norm for systematic reviews of RCTs, so the discussion will contrast the implications for systematic reviews of NRS and RCTs.
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