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Assessing the risk of outcome reporting bias in systematic reviews

Topic category Investigating bias
Date and Location
Date: 
Saturday 22 October 2011 - 14:00 - 15:30
Location: 
Methods Group
Methods Group: 
Bias Methods Group
Contact person
Contact person: 
Kerry Dwan (Contact this person)
Facilitators
First nameLast nameAffiliation and Country
First name: 
Kerry
Last name: 
Dwan
Affiliation and Country: 
The University of Liverpool, UK
First name: 
Jamie
Last name: 
Kirkham
Affiliation and Country: 
The University of Liverpool, UK
First name: 
Paula
Last name: 
Williamson
Affiliation and Country: 
The University of Liverpool, UK
Other contributors
First nameLast nameAffiliation and Country
First name: 
Doug
Last name: 
Altman
Affiliation and Country: 
Center for Statistics in Medicine, UK
Target audience
Target audience: 
Review authors, trialists, consumers, and researchers with a particular interest
Is your workshop restricted to a specific audience or open to all Colloquium participants?: 
Open
Level of knowledge required: 
Intermediate
Type of workshop
Type of workshop: 
Training
Abstract text
Abstract: 
Objectives:
To provide the reviewer with a background to the problem of outcome reporting bias and how it might lead to misleading conclusions, to demonstrate how a reviewer might identify such bias in their review, and to present techniques for assessing the robustness of the meta-analysis to such bias.

Description:
Within-study selective reporting has been defined as the selection, on the basis of the results, of a subset of the analyses undertaken to be included in a study publication. Sources of bias will be described. The workshop will focus on outcome reporting bias (ORB).

Empirical evidence for the existence of ORB is accumulating. In a meta-analysis, often a total number of k eligible studies are identified but only n report the data of interest. The reviewer needs to examine the remaining (k-n) studies to establish whether the outcome of interest was collected but not reported.

Methods for the identification of ORB in a meta-analysis and an individual study will be described and illustrated using examples.

Participants will be encouraged to undertake such assessments for examples provided and to discuss issues for their reviews.